منابع مشابه
Genetics of cardiomyopathy and channelopathy
During the past 20 years, we have witnessed a dramatic increase in our knowledge of the genetic basis of the cardiomyopathies and the primary electrical disorders (‘‘ion channelopathies’’). This review aims to provide an overview of the different genes linked to these disorders to date. Heart Metab. 2008;41:5–10.
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Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation. It seems likely that aberrant peripheral ...
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Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells.
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Prostate cancer is the most common cancer in males and the second leading cause of cancer deaths in western countries. Although most prostate cancers initially respond well to androgen withdrawal, they become inevitably resistant to this treatment and progress to hormone-insensitive disease after only a few months or years. The therapeutic options in these advanced tumors are very limited. The ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2019
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201912457